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The Philadelphia Chromosome: A Mutant Gene And The Quest To Cure Cancer At The Genetic Level (2013)

by Jessica Wapner(Favorite Author)

4.34 of 5 Votes: 5

ISBN

1615190678 (ISBN13: 9781615190676)

languge

English

genre

History & Biography

publisher

The Experiment

review 1: Well-researched by the author. I am surprised at how much biochem I remembered. Creating inhibitors for mutant protein kinases that occur in certain cancers with cells that exhibit the Philadelphia (broken) chromosome. A great account of the scientific detective work and fortuitous unrelated findings. One of them being the use of the wrong buffer in an enzyme experiment, remember to own up to your mistakes in the lab, you never know what discoveries they might uncover! Too bad this treatment cannot be used in more types of cancer - as yet anyway.
review 2: The first half of this book is was confusing and convoluted for me - lots of Scientists' names and science history, and I found it hard to keep track of the story (also chapters are fairly short which did not... more let me get too engrossed for too long). But by the second half I was racing to finish (even though we know the ending from the start) - plus I learned a great deal about the history of cancer treatment and drug development. The story of CML and the Philadelphia chromosome is definitely worth reading about, since scientific research rarely leads to such a clear cut path like described in the book. less

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